With his shot from the right corner with 4 1/2 minutes to play, Ballock joined Kyle Korver and Ethan Wragge as Bluejays to reach that milestone as juniors.
Creighton pulled away in the second half when the Bluejays made 5 of 11 3-pointers and shot 56.6% overall. They were 5 of 14 from distance in the first half when they led just 37-34.
Denzel Mahoney and Damien Jefferson added 14 points apiece for the Bluejays (15-5, 4-3 Big East Conference), Ty-Shon Alexander scored 12 and Christian Bishop 11. Marcus Zegarowski grabbed 10 rebounds to go with nine points.
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Paul Reed had his 13th double-double of the season with 22 points and 12 rebounds plus three blocks for the Blue Demons (13-6, 1-5). Charlie Moore added 13 points and seven assists and Jalen Coleman-Lands had 11 points.
DePaul was just 3 of 16 behind the arc, 1 of 7 in the second half when the Blue Demons shot 41%.